ציטוט:
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פורסם במקור על ידי THE_JUGGERNAUT
יש מצב שאתה נותן את המחקרים?
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זה מבוסס על מחקרים של IF. יש על זה דיונים וחפירות מפה ועד הודעה חדשה בפורום של לייל. הנה האבסטרקט של המחקר בכל אופן...
Halberg, Nils, Morten Henriksen, Nathalie So¨derhamn, Bente
Stallknecht, Thorkil Ploug, Peter Schjerling, and Flemming Dela.
Effect of intermittent fasting and refeeding on insulin action in healthy
men.
J Appl Physiol 99: 2128–2136, 2005. First published July 28,
2005; doi:10.1152/japplphysiol.00683.2005.—Insulin resistance is
currently a major health problem. This may be because of a marked
decrease in daily physical activity during recent decades combined
with constant food abundance. This lifestyle collides with our genome,
which was most likely selected in the late Paleolithic era
(50,000 –10,000 BC) by criteria that favored survival in an environment
characterized by fluctuations between periods of feast and
famine. The theory of thrifty genes states that these fluctuations are
required for optimal metabolic function. We mimicked the fluctuations
in eight healthy young men [25.0 0.1 yr (mean SE); body
mass index: 25.7 0.4 kg/m2] by subjecting them to intermittent
fasting every second day for 20 h for 15 days. Euglycemic hyperinsulinemic
(40 mUmin1 m2) clamps were performed before and
after the intervention period. Subjects maintained body weight
(86.4 2.3 kg; coefficient of variation: 0.8 0.1%). Plasma free fatty
acid and -hydroxybutyrate concentrations were 347 18 and 0.06
0.02 mM, respectively, after overnight fast but increased (
P 0.05)
to 423 86 and 0.10 0.04 mM after 20-h fasting, confirming that
the subjects were fasting. Insulin-mediated whole body glucose uptake
rates increased from 6.3 0.6 to 7.3 0.3 mgkg1 min1
(
P 0.03), and insulin-induced inhibition of adipose tissue lipolysis
was more prominent after than before the intervention (P 0.05).
After the 20-h fasting periods, plasma adiponectin was increased
compared with the basal levels before and after the intervention
(5,922 991 vs. 3,860 784 ng/ml, P 0.02). This experiment is
the first in humans to show that intermittent fasting increases insulinmediated
glucose uptake rates, and the findings are compatible with
the thrifty gene concept.
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